Topical Delivery of Immunosuppression to Prolong Xenogeneic and Allogeneic Split-Thickness Skin Graft Survival
نویسندگان
چکیده
منابع مشابه
Agonistic CD200R1 DNA Aptamers Are Potent Immunosuppressants That Prolong Allogeneic Skin Graft Survival
CD200R1 expressed on the surface of myeloid and lymphoid cells delivers immune inhibitory signals to modulate inflammation when engaged with its ligand CD200. Signalling through CD200/CD200R1 has been implicated in a number of immune-related diseases including allergy, infection, cancer and transplantation, as well as several autoimmune disorders including arthritis, systemic lupus erythematosu...
متن کاملThymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival.
We have demonstrated that murine thymic dendritic cells (DCs) isolated from donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous injections, where they induce T cell deletions and prolong donor-strain airway and skin graft survival. In contrast, infused splenic DCs immigrated poorly to thymi, and did not affect graft survival. These findings suggest t...
متن کاملImproved Healing of Split Thickness Skin Graft Donor Sites
Cosmetically unacceptable pigmentation changes and hypertrophic scarring often complicate split thickness skin graft (STSG) donor sites. In fact, patients often ask about other alternatives when confronted with the need to harvest STSG, particularly because they fear additional disfigurement. Because recent evidence suggests that a moist environment promotes more optimal healing, we conducted a...
متن کاملDressings for split thickness skin graft donor sites.
Background: The management of donor sites after harvesting of split thickness skin grafts is a challenge. Aim: The aim of this study was to compare three different dressings for split thickness skin donor sites. Methods: This study was designed as a prospective comparative study of 60 patients allocated to one of three donor site dressings groups, following harvesting of split skin. The first a...
متن کاملSplit Thickness Skin Graft Donor Sites: Post Harvest Management
All studies were categorised according to the strength of the evidence based on the following revised classification system. Level I Evidence obtained from a systematic review of all relevant randomised controlled trials. Level II Evidence obtained from at least one properly designed randomised controlled trial. Level III.1 Evidence obtained from well designed pseudo-randomised controlled trial...
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ژورنال
عنوان ژورنال: Journal of Burn Care & Research
سال: 2017
ISSN: 1559-047X
DOI: 10.1097/bcr.0000000000000597